Internally, small amounts of leaves strongly promote perspiration and bowel clean up the next day. Fresh grass juice is sometimes used for fever and pain. High doses of black nightshade can cause serious but generally not fatal, poisoning. Externally, the juice or cream is made of leaves can be used for skin problems and cancer. The berries are poisonous, but boiling apparently destroys the toxic substances [...]

It is recognized by the United States Pharmacopoeia. It is useful in constipation normal. It lowers bowels, increases peristaltic action in the colon by its local action on the intestinal wall. It is used as an expectorant, carminative, chest injury, antidysentric and laxative.